The Genetics Journal Club

The goal of the journal club is to bring together researchers, technicians and students interested in research applications of genetics. On each meeting, an assigned participant will present one scientific article of his or her choice to the group to open the discussion. Presentations are either in French or English at the choice of the person making the presentation. Paper topics include pharmacogenomics, cardiology and inflammation, making some use or application of genetics.

Meetings are scheduled on alternating Thursdays from 12:00 to 1:00pm in room S3200 at the Montreal Heart Institute. Assigned presenters are asked to send their article on the Friday preceding the presentation.  

To request information or to join the journal club, please send an email request to Marie-Pierre Dubé.  marie-pierre.dube [ at] statgen.org  

Meeting schedule :

SEPTEMBER 21 - Marie-Pierre Dubé 

Evolution of primate gene expression. Khaitovich P, Enard W, Lachmann M, Paabo S; Nat Rev Genet. 2006 Sep;7(9):693-702   

OCTOBER 5 - Ian Mongrain 

Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease. Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH; N Engl J Med. 2006; 354:1264-72

OCTOBER 19 - Céline Lefebvre

Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI, Fugger L; Nature. 2006 Oct 5;443(7111):574-7   

NOVEMBER 2 - Andrew Brown

The Consensus Coding Sequences of Human Breast and Colorectal Cancers. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE; Science. 2006 Oct 13;314(5797):268-74   

NOVEMBER 16 - Catherine Labbé

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH; Science. 2006 Dec 1;314(5804):1461-3  

NOVEMBER 30 - Claudia Reinhard

Genome-wide analysis of estrogen receptor binding sites. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M; Nat Genet. 2006 Nov;38(11):1289-97   

DECEMBER 14 - Simon deDenus  

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Liggett SB, Mialet-Perez J, Thaneemit-Chen S, Weber SA, Greene SM, Hodne D, Nelson B, Morrison J, Domanski MJ, Wagoner LE, Abraham WT, Anderson JL, Carlquist JF, Krause-Steinrauf HJ, Lazzeroni LC, Port JD, Lavori PW, Bristow MR. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11288-93

JANUARY 18 - John Rioux  

A Three–Single-Nucleotide Polymorphism Haplotype in Intron 1 of OCA2 Explains Most Human Eye-Color Variation. David L. Duffy, Grant W. Montgomery, Wei Chen, Zhen Zhen Zhao, Lien Le, Michael R. James, Nicholas K. Hayward, Nicholas G. Martin, and Richard A. Sturm, American Journal of Human Genetics, 2007 Feb; 80(2); 241-252

FEBRUARY 1 - Amina Barhdadi  

A tutorial on statistical methods for population association studies. David J. Balding. Nature Genetics, 2006, Oct7(10); 781-791

FEBRUARY 15 - Nathalie Laplante  

The social and ethical issues of post-genomic human biobanks. Anne Cambon-Thomsen. Nature Reviews Genetics, 2004 Nov;5(11):866-73 

MARCH 1-    

*Cancelled*

MARCH 29 - Marie-Pierre Dubé 

Genetic Analysis of 103 Candidate Genes for Coronary Artery Disease and Associated Phenotypes in a Founder Population Reveals a New Association between Endothelin-1 and High-Density Lipoprotein Cholesterol Guillaume Paré, David Serre, Diane Brisson, Sonia S. Anand, Alexandre Montpetit, Gérald Tremblay, James C. Engert, Thomas J. Hudson, and Daniel Gaudet.  American Journal of Human Genetics 2007 April; 80:673-682

APRIL 26 - Sylvie Provost

Environmental epigenomics and disease susceptibility. Jirtle RL, Skinner MK. Nat Rev Genet. 2007 Apr;8(4):253-62

MAY 10 - Philippe Goyette

A Common Allele on Chromosome 9 Associated with Coronary Heart Disease. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC. Science. 2007 May 3; [Epub ahead of print]