2010

Partitioning of copy-number genotypes in pedigrees. Lemieux Perreault LP*, Andelfinger G, Asselin G*, Dubé MP*. BMC Bioinformatics 2010, 11:226

Mutations in DCC Cause Congenital Mirror Movements. Srour M, Rivière JB, Pham JMT, Dubé MP*, Girard S, Morin S, Dion PA, Asselin G*, Rochefort D, Hince P, Diab S, Sharafaddinzadeh N, Chouinard S, Théoret H, Charron F, Rouleau GA.  Science, 30 April 2010:Vol. 328. no. 5978, p. 592

De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Gauthier J, Champagne N, Lafrenière RG, Xiong L, Spiegelman D, Brustein E, Lapointe M, Peng H, Côté M, Noreau A, Hamdan FF, Addington AM, Rapoport JL, Delisi LE, Krebs MO, Joober R, Fathalli F, Mouaffak F, Haghighi AP, Néri C, Dubé MP*, Samuels ME, Marineau C, Stone EA, Awadalla P, Barker PA, Carbonetto S, Drapeau P, Rouleau GA; the S2D Team. Proc Natl Acad Sci U S A. 2010 Apr 12. [Epub ahead of print]

Genetic determinants of blood pressure reduction following potassium supplementation : and the candidates are? deDenus S, Dubé MP*.  Journal of Hypertension. 28(4):668-670, April 2010

Genome-wide TDT analysis in French-Canadian families with Tourette syndrome. Rivière JB, St-Onge J, Gaspar C, Diab S, Dion Y, Lespérance P, Tellier G, Richer F, Chouinard S, Dubé MP*, Rouleau GA. Montreal Tourette Study Group. Can J Neurol Sci. 2010 Jan;37(1):110-2.

Genetics of bronchopulmonary dysplasia in the age of genomics. Lavoie P, Dubé MP*. Current Opinion in Pediatrics,2010 Apr;22(2):134-8

Testing for Gene-Gene Interaction with AMMI Models. Barhdadi A, Dubé MP*. Statistical Applications in Genetics and Molecular Biology 2010, Vol. 9 :Iss. 1, Article 2.

Novel mutations in the sacsin gene in ataxia patients from Maritime Canada. Guernsey DL, Dubé MP*, Jiang H, Asselin G*, Blowers S, Evans S, Ferguson M, Macgillivray C, Matsuoka M, Nightingale M, Rideout A, Delatycki M, Orr A, Ludman M, Dooley J, Riddell C, Samuels ME. J Neurol Sci. 2010 Jan 15;288(1-2):79-87

2009

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A*, Feroz-Zada Y*, Visscher H, Brown AM, Rieder MJ, Rogers PC, Phillips MS, Carleton BC, Hayden MR; the CPNDS Consortium. Nature Genetics, 2009 Dec;41(12):1345-9.

Different models and single-nucleotide polymorphisms signal the simulated weak gene-gene interaction for a quantitative trait using haplotype-based and mixed models testing. Kovac IP*, Dubé MP*. BMC Proc. 2009 Dec 15;3 Suppl 7:S77.

The challenge of detecting epistasis (GxG Interactions): Genetic Analysis Workshop 16. An P, Mukherjee O, Chanda P, Yao L, Engelman CD, Huang CH, Zheng T, Kovac IP*, Dubé MP*, Liang X, Li J, de Andrade M, Culverhouse R, Malzahn D, Manning AK, Clarke GM, Jung J, Province MA. Genet Epidemiol. 2009 Nov 18; 33(S1):S58-S67.

Application of principal component analysis to pharmacogenomic studies in Canada. Visscher H, Ross CJ, Dubé MP*, Brown AM, Phillips MS, Carleton BC, Hayden MR. Pharmacogenomics J. 2009 Aug 4.  

Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel. 2. Carruthers H, Rusbridge C, Dubé MP*, Holmes M, Jeffery N. J Small Anim Pract. 2009 Aug;50(8):394-8 

Mutation in pyrroline-5-carboxylate reductase 1 gene in families with cutis laxa type 2. Guernsey DL, Jiang H, Evans SC, Ferguson M, Matsuoka M, Nightingale M, Rideout AL, Provost S*, Bedard K, Orr A, Dubé MP*, Ludman M, Samuels ME. Am J Hum Genet. 2009 Jul;85(1):120-9

Genetic Modulation of Brugada Syndrome by a Common Polymorphism. Lizotte E, Junttila MJ, Dubé MP*, Hong K, Benito B, DE Zutter M, Henkens S, Sarkozy A, Huikuri HV, Towbin J, Vatta M, Brugada P, Brugada J, Brugada R. J Cardiovasc Electrophysiol. 2009 Jun 22

Application of Homozygosity Haplotype Analysis to Genetic Mapping with High-Density SNP Genotype Data. Jiang H, Orr A, Guernsey DL, Robitaille J, Asselin G*, Samuels ME, Dubé MP*. PLoS ONE 2009; 4(4):e5280. Apr 28

Genetic predictors of depressive symptoms in cardiac patients. McCaffery JM, Duan QL, Frasure-Smith N, Barhdadi A*, Lespérance F, Théroux P, Rouleau GA, Dube MP*. Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):381-8

Autosomal-dominant locus for restless legs syndrome in French-Canadians on chromosome 16p12.1. Levchenko A, Montplaisir JY, Asselin G*, Provost S*, Girard SL, Xiong L, Lemyre E, St-Onge J, Thibodeau P, Desautels A, Turecki G, Gaspar C, Dubé MP*, Rouleau GA. Mov Disord. 2009 Jan 15;24(1):40-50.

2008

Génome Québec & Montreal Heart Institute Pharmacogenomics Centre: a translational pharmacogenomics platform--from R&D to the clinic. Phillips MS, Hihi AK, van Rooij T, Smith AC, James S, Marsh S, Laplante N, Dubé MP*, Tardif JC. Pharmacogenomics. 2008 Oct;9(10):1391-6.

Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Champagne N, Lafrenière RG, Hamdan FF; S2D team; Joober R, Fombonne E, Marineau C, Cossette P, Dubé MP*, Haghighi P, Drapeau P, Barker PA, Carbonetto S, Rouleau GA. Hum Mol Genet. 2008 Dec 15;17(24):3965-74

A survey of the personalized medicine landscape. Ozdemir V, Dubé MP*, Tardif JC, de Denus S, Phillips M, Stenne R, Shimoda K, Someya T, Godard B. Pharmacogenomics. 2008 Jul;9(7):819-823

Effects of AGTR1 A1166C Gene Polymorphism in Patients with Heart Failure Treated with Candesartan. de Denus S, Zakrzewski-Jakubiak M, Dubé MP*, Bélanger F, Lepage S, Leblanc MH, Gossard D, Ducharme A, Racine N, Whittom L, Lavoie J, Touyz RM, Turgeon J, White M.Ann Pharmacother. 2008 Jul 1; [Epub ahead of print]

A novel locus for idiopathic generalized epilepsy in French-Canadian families maps to 10p11. Kinirons P, Verlaan DJ, Dubé MP*, Poirier J, Deacon C, Lortie A, Clément JF, Desbiens R, Carmant L, Cieuta-Walti C, Shevell M, Rouleau GA, Cossette P. Am J Med Genet A. 2008 Mar 1;146A(5):578-84

Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure. Zakrzewski-Jakubiak M, de Denus S, Dubé MP*, Bélanger F, White M, Turgeon J. Br J Clin Pharmacol. 2008 May;65(5):742-51

No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. Bolduc V, Chagnon P, Provost S, Dube MP*, Belisle C, Gingras M, Mollica L, Busque L. J Clin Invest. 2008 Jan;118(1):333-41

2007

Two-stage strategies to detect gene x gene interactions in case-control data. Barhdadi A*, Dube MP*. BMC Proc. 2007;1 Suppl 1:S135

Multistage Designs in the Genomic Era: Providing Balance in Complex Disease Studies. Dube MP*, Schmidt S, Hauser E. Genetic Epidemiology, 31 (Supplement 1):S1–S6, 2007

Genetics of Congenital Amusia (or tone-deafness): A Family Aggregation Study. I Peretz, S Cummings, MP Dubé*. American Journal of Human Genetics, 2007 Sep;81(3):582-8

Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy. Orr A, Dubé MP*, Marcadier J, Jiang H, Federico A, George S, Seamone C, Andrews D, Dubord P, Holland S, Provost S, Mongrain V, Evans S, Higgins B, Bowman S, Guernsey D, Samuels M. PLoS ONE. 2007 Aug 1;2(1):e685

Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. Rusbridge C, Carruthers H, Dubé MP*, Holmes M, Jeffery ND. J Small Anim Pract. 2007 Aug;48(8):432-6

Gene-Gene Interaction Tests Using SVM and Neural Network Modeling. N Martchenko-Shimko*, MP Dubé*. Computational Intelligence in Bioinformatics and Computational Biology, 2007. CIBCB '07. Proceedings of the 2007 IEEE Symposium

Loss-of-function mutations in the Nav1. 7 gene underlie congenital indifference to pain in multiple human populations. Goldberg YP, MacFarlane J, MacDonald ML, Thompson J, MP Dubé*, Mattice M, Fraser R, Young C, Hossain S, Pape T, Payne B, Radomski C, Donaldson G, Ives E, Cox J, Younghusband HB, Green R, Duff A, Boltshauser E, Grinspan GA, Dimon JH, Sibley BG, Andria G, Toscano E, Kerdraon J, Bowsher D, Pimstone SN, Samuels ME, Sherrington R, Hayden MR. Clin Genet 2007, Apr;71(4):311-9

New Technologies in Human Genetic Analysis. ME Samuels, B Higgins, S Provost, J Marcadier, C Blouin, S Bowman, MP Dubé*. American Biotechnology Laboratory 2007, 25 (5): 22-28

Gene-Gene Interaction Tests Using SVM and Neural Network Modeling. N Martchenko-Shimko*, MP Dubé*. Computational Intelligence in Bioinformatics and Computational Biology, 2007. CIBCB '07. Proceedings of the 2007 IEEE Symposium

Additive effects of obesity and TCF7L2 variants on risk for type 2 diabetes among cardiac patients. QL Duan, MP Dubé*, F Lesperance, P Théroux, J St-Onge, GA,N Frasure-Smith, A Barhdadi*, Rouleau, J McCaffery. Diabetes Care. 2007 Jun;30(6):1621-3

Lamin A/C mutations associated with familial and sporadic cases of dilated cardiomyopathy in Koreans. K Song, MP Dubé*, J Lim, I Hwang, I Lee, JJ Kim. Exp Mol Med. 2007 Feb 28; 39(1):114-120

2006

Bootstrap Inference with Neural-Network Modeling for Gene-Disease Association Testing N Martchenko-Shimko, MP Dubé*. Computational Intelligence in Bioinformatics and Computational Biology, 2006. CIBCB '06. Proceedings of the 2006 IEEE Symposium.

A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13 A Levchenko, S Provost*, JY Montplaisir, L Xiong, J St-Onge, P Thibodeau, JB Riviere, A Desautels, G Turecki, MP Dubé*, GA Rouleau. Neurology. 2006 Sep 12;67(5):900-1

A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15. 2-14. 3 DJ Verlaan, MP Dubé*, J St-Onge, A Noreau, J Roussel, N Satgé, MC Wallace, GA Rouleau. Journal Of Medical Genetics 43 (6): e31

Human Monogenic Disorders- a Source of Novel Drug Targets RR Brinkman, M-P Dubé*, GA Rouleau, A Orr, ME Samuels. Nature Reviews Genetics 7, 249-260, April 2006

Common Genetic Vulnerability to Depressive Symptoms and Coronary Artery Disease: A Review and Development of Candidate Genes Related to Inflammation and Serotonin JM McCaffery, N Frasure-Smith, MP Dubé*, P Theroux, GA Rouleau, QL Duan, F Lesperance. Psychosomatic Medicine. 68(2):187-200, March/April 2006

Autism spectrum disorders associated with X chromosome markers in French-Canadian males J Gauthier, R Joober, M-P Dubé*, J St-Onge, A Bonnel, D Gariépy, S Laurent, R Najafee, H Lacasse, L St-Charles, É Fombonne, L Mottron, G A Rouleau. Molecular Psychiatry 11 (2): 206-213 Feb 2006

2005

Chromosome 11-q24 region in Tourette Syndrome: Association and linkage disequilibrium study in the French Canadian population A Díaz-Anzaldúa, J-B Rivière, M-P Dubé*, R Joober, J Saint-Onge, Y Dion, P Lespérance, F Richer, S Chouinard, G A Rouleau and the Montreal Tourette Syndrome Study Group. The American Journal of Medical Genetics Part A, 138A (3): 225-228, Oct 15 2005

A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors QL Duan, B Nikpoor, M-P Dubé*, G Molinaro, IA Meijer, P Dion, D Rochefort, J Saint-Onge, L Flury, NJ Brown, JV Gainer, JL Rouleau, A Agostoni, M Cugno, P Simon, P Clavel, J Potier, B Wehbe, S Benarbia, J Marc-Aurèle, J Chanard, T Foroud, A Adam, GA Rouleau. American Journal of Human Genetics 77:617-626, 2005

Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24. 31 region E Shink, M Harvey, M Tremblay, B Gagné, P Belleau, C Raymond, M Labbé, MP Dubé*, RG Lafrenière, N Barden American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics 135B (1): 50-58 May 5 2005