2008

A survey of the personalized medicine landscapeOzdemir V, Dubé MP, Tardif JC, de Denus S, Phillips M, Stenne R, Shimoda K, Someya T, Godard B. Pharmacogenomics. 2008 Jul;9(7):819-823

Effects of AGTR1 A1166C Gene Polymorphism in Patients with Heart Failure Treated with Candesartande Denus S, Zakrzewski-Jakubiak M, Dubé MP, Bélanger F, Lepage S, Leblanc MH, Gossard D, Ducharme A, Racine N, Whittom L, Lavoie J, Touyz RM, Turgeon J, White M.Ann Pharmacother. 2008 Jul 1; [Epub ahead of print]

Genetic predictors of depressive symptoms in cardiac patients. McCaffery JM, Duan QL, Frasure-Smith N, Barhdadi A, Lespérance F, Théroux P, Rouleau GA, Dube MP. Neuropsychiatric Genetics, Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 10. [Epub ahead of print]

A novel locus for idiopathic generalized epilepsy in French-Canadian families maps to 10p11. Kinirons P, Verlaan DJ, Dubé MP, Poirier J, Deacon C, Lortie A, Clément JF, Desbiens R, Carmant L, Cieuta-Walti C, Shevell M, Rouleau GA, Cossette P. Am J Med Genet A. 2008 Mar 1;146A(5):578-84

Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure. Zakrzewski-Jakubiak M, de Denus S, Dubé MP, Bélanger F, White M, Turgeon J. Br J Clin Pharmacol. 2008 May;65(5):742-51

No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. Bolduc V, Chagnon P, Provost S, Dube MP, Belisle C, Gingras M, Mollica L, Busque L. J Clin Invest. 2008 Jan;118(1):333-41

2007

Two-stage strategies to detect gene x gene interactions in case-control data. Barhdadi A, Dube MP. BMC Proc. 2007;1 Suppl 1:S135

Multistage Designs in the Genomic Era: Providing Balance in Complex Disease Studies. Dube MP, Schmidt S, Hauser E. Genetic Epidemiology, 31 (Supplement 1):S1–S6, 2007

Genetics of Congenital Amusia (or tone-deafness): A Family Aggregation Study. I Peretz, S Cummings, MP Dubé. American Journal of Human Genetics, 2007 Sep;81(3):582-8

Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy. Orr A, Dubé MP, Marcadier J, Jiang H, Federico A, George S, Seamone C, Andrews D, Dubord P, Holland S, Provost S, Mongrain V, Evans S, Higgins B, Bowman S, Guernsey D, Samuels M. PLoS ONE. 2007 Aug 1;2(1):e685

Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. Rusbridge C, Carruthers H, Dubé MP, Holmes M, Jeffery ND. J Small Anim Pract. 2007 Aug;48(8):432-6

Gene-Gene Interaction Tests Using SVM and Neural Network Modeling. N Martchenko-Shimko, MP Dubé. Computational Intelligence in Bioinformatics and Computational Biology, 2007. CIBCB '07. Proceedings of the 2007 IEEE Symposium

Loss-of-function mutations in the Nav1. 7 gene underlie congenital indifference to pain in multiple human populations. Goldberg YP, MacFarlane J, MacDonald ML, Thompson J, MP Dubé, Mattice M, Fraser R, Young C, Hossain S, Pape T, Payne B, Radomski C, Donaldson G, Ives E, Cox J, Younghusband HB, Green R, Duff A, Boltshauser E, Grinspan GA, Dimon JH, Sibley BG, Andria G, Toscano E, Kerdraon J, Bowsher D, Pimstone SN, Samuels ME, Sherrington R, Hayden MR. Clin Genet 2007, Apr;71(4):311-9

New Technologies in Human Genetic Analysis. ME Samuels, B Higgins, S Provost, J Marcadier, C Blouin, S Bowman, MP Dubé. American Biotechnology Laboratory 2007, 25 (5): 22-28

Gene-Gene Interaction Tests Using SVM and Neural Network Modeling. N Martchenko-Shimko, MP Dubé. Computational Intelligence in Bioinformatics and Computational Biology, 2007. CIBCB '07. Proceedings of the 2007 IEEE Symposium

Additive effects of obesity and TCF7L2 variants on risk for type 2 diabetes among cardiac patients. QL Duan,MP Dubé, F Lesperance, P Théroux, J St-Onge, GA,N Frasure-Smith, A Barhdadi Rouleau, J McCaffery. Diabetes Care. 2007 Jun;30(6):1621-3

Lamin A/C mutations associated with familial and sporadic cases of dilated cardiomyopathy in Koreans. K Song, MP Dubé, J Lim, I Hwang, I Lee, JJ Kim. Exp Mol Med. 2007 Feb 28; 39(1):114-120

2006

Bootstrap Inference with Neural-Network Modeling for Gene-Disease Association Testing N Martchenko-Shimko, MP Dubé. Computational Intelligence in Bioinformatics and Computational Biology, 2006. CIBCB '06. Proceedings of the 2006 IEEE Symposium.

A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13 A Levchenko, S Provost, JY Montplaisir, L Xiong, J St-Onge, P Thibodeau, JB Riviere, A Desautels, G Turecki, MP Dubé, GA Rouleau. Neurology. 2006 Sep 12;67(5):900-1

A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15. 2-14. 3 DJ Verlaan, MP Dubé, J St-Onge, A Noreau, J Roussel, N Satgé, MC Wallace, GA Rouleau. Journal Of Medical Genetics 43 (6): e31

Human Monogenic Disorders- a Source of Novel Drug Targets RR Brinkman, M-P Dubé, GA Rouleau, A Orr, ME Samuels. Nature Reviews Genetics 7, 249-260, April 2006

Common Genetic Vulnerability to Depressive Symptoms and Coronary Artery Disease: A Review and Development of Candidate Genes Related to Inflammation and Serotonin JM McCaffery, N Frasure-Smith, MP Dubé, P Theroux, GA Rouleau, QL Duan, F Lesperance. Psychosomatic Medicine. 68(2):187-200, March/April 2006

Autism spectrum disorders associated with X chromosome markers in French-Canadian males J Gauthier, R Joober, M-P Dubé, J St-Onge, A Bonnel, D Gariépy, S Laurent, R Najafee, H Lacasse, L St-Charles, É Fombonne, L Mottron, G A Rouleau. Molecular Psychiatry 11 (2): 206-213 Feb 2006

2005

Chromosome 11-q24 region in Tourette Syndrome: Association and linkage disequilibrium study in the French Canadian population A Díaz-Anzaldúa, J-B Rivière, M-P Dubé, R Joober, J Saint-Onge, Y Dion, P Lespérance, F Richer, S Chouinard, G A Rouleau and the Montreal Tourette Syndrome Study Group. The American Journal of Medical Genetics Part A, 138A (3): 225-228, Oct 15 2005

A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors QL Duan,* B Nikpoor*, M-P Dubé, G Molinaro, IA Meijer, P Dion, D Rochefort, J Saint-Onge, L Flury, NJ Brown, JV Gainer, JL Rouleau, A Agostoni, M Cugno, P Simon, P Clavel, J Potier, B Wehbe, S Benarbia, J Marc-Aurèle, J Chanard, T Foroud, A Adam, GA Rouleau. American Journal of Human Genetics 77:617-626, 2005

Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24. 31 region E Shink, M Harvey, M Tremblay, B Gagné, P Belleau, C Raymond, M Labbé, MP Dubé, RG Lafrenière, N Barden American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics 135B (1): 50-58 May 5 2005

2007

2006

Bootstrap Inference with Neural-Network Modeling for Gene-Disease Association Testing  N Martchenko-Shimko, MP Dubé.  Computational Intelligence in Bioinformatics and Computational Biology, 2006. CIBCB '06. Proceedings of the 2006 IEEE Symposium. 

A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13  A Levchenko, S Provost, JY Montplaisir, L Xiong, J St-Onge, P Thibodeau, JB Riviere, A Desautels, G Turecki, MP Dubé, GA Rouleau.  Neurology. 2006 Sep 12;67(5):900-1 (PubMed)

A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15.2-14.3  DJ Verlaan, MP Dubé, J St-Onge, A Noreau, J Roussel, N Satgé, MC Wallace, GA Rouleau.  Journal Of Medical Genetics 43 (6): e31 (PubMed)    

Human Monogenic Disorders- a Source of Novel Drug Targets  RR Brinkman, M-P Dubé, GA Rouleau, A Orr, ME Samuels.  Nature Reviews Genetics 7, 249-260, April 2006 (PubMed)

Common Genetic Vulnerability to Depressive Symptoms and Coronary Artery Disease: A Review and Development of Candidate Genes Related to Inflammation and Serotonin  JM McCaffery, N Frasure-Smith, MP Dubé, P Theroux, GA Rouleau, QL Duan, F Lesperance.  Psychosomatic Medicine. 68(2):187-200, March/April 2006 (PubMed)

Autism spectrum disorders associated with X chromosome markers in French-Canadian males  J Gauthier, R Joober, M-P Dubé, J St-Onge, A Bonnel, D Gariépy, S Laurent, R Najafee, H Lacasse, L St-Charles, É Fombonne, L Mottron, G A Rouleau.  Molecular Psychiatry 11 (2): 206-213 Feb 2006 (PubMed)

2005

Chromosome 11-q24 region in Tourette Syndrome: Association and linkage disequilibrium study in the French Canadian population  A Díaz-Anzaldúa, J-B Rivière, M-P Dubé, R Joober, J Saint-Onge, Y Dion, P Lespérance, F Richer, S Chouinard, G A Rouleau and the Montreal Tourette Syndrome Study Group.  The American Journal of Medical Genetics Part A, 138A (3): 225-228, Oct 15 2005  (PubMed)

A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors  QL Duan,* B Nikpoor*, M-P Dubé, G Molinaro, IA Meijer, P Dion, D Rochefort, J Saint-Onge, L Flury, NJ Brown, JV Gainer, JL Rouleau, A Agostoni, M Cugno, P Simon, P Clavel, J Potier, B Wehbe, S Benarbia, J Marc-Aurèle, J Chanard, T Foroud, A Adam, GA Rouleau.  American Journal of Human Genetics 77:617-626, 2005 (PubMed)

Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region E Shink, M Harvey, M Tremblay, B Gagné, P Belleau, C Raymond, M Labbé, MP Dubé, RG Lafrenière, N Barden American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics 135B (1): 50-58 May 5 2005  (PubMed)